Research:

Keywords:

immunoengineering, biomaterials, drug delivery, gene therapy, translational research

Research Activities

Our Bioengineering lab in the Departments of Biomedical Engineering, Ophthalmology, Oncology, Neurosurgery, Materials Science & Engineering, and Chemical and Biomolecular Engineering at the Johns Hopkins University is especially interested in the design of biotechnologies and therapeutics. We design and synthesize new biomaterials and particle systems that can deliver biomolecules such as peptides, proteins, nucleic acids, and small molecules specifically to various cell types, including immune cells, cancer cells and stem cells. Our lab is committed to the development of enabling nanobiotechnology and elucidating their mechanisms as part of the Institute for Nanobiotechnology at JHU including the development of immunotherapies as Co-Director of the Translational ImmunoEngineering Center, targeted anti-cancer therapeutics as part of the Sidney Kimmel Comprehensive Cancer Center, regenerative medicine cellular therapies as part of the Translational Therapeutics and Regenerative Engineering Center, and ocular therapies as part of the Wilmer Eye Institute.

Summary of Research Program

Dr. Green’s Biomaterials and Drug Delivery Laboratory is interested in biomaterials, drug delivery, gene therapy, nanobiotechnology, and cell engineering. Research findings — and the technologies developed — are applied in the fields of immunology, ophthalmology, oncology, and regenerative medicine.
The lab works within the chemistry/biology/engineering interface to answer fundamental scientific questions, and to create innovative technologies and therapeutics that can directly benefit human health.
Current projects include:
1. Development of next generation mRNA vaccines for cancer, autoimmune diseases, and infectious diseases.
2. Design and development of in vivo cell engineering systems for CAR Ts, CAR Macrophages, and CAR NKs.
3. Safe and effective biodegradable reprogramming nanoparticles for DNA and siRNA delivery to treat cancer
4. Polymeric microparticle-based biological treatments for age-related macular degeneration
5. Design of biomimetic artificial antigen presenting cells for immunoengineering
6. Enabling technologies for tissue engineering and regenerative medicine

Publications and Interests: https://www.bme.jhu.edu/people/faculty/jordan-j-green/