Research:

Key words: HCV, broadly neutralizing antibodies, resistance

My laboratory is currently focused on studies of B cell and broadly neutralizing antibody responses against hepatitis C virus (HCV), hepatitis B virus (HBV) and SARS-CoV-2. A particular technical strength of my group is high dimensional flow cytometric analysis of antigen-specific B cells, which allows us to phenotype these rare cells, and also to sequence B cell receptor (BCR) repertoires and isolate virus-neutralizing monoclonal antibodies (mAbs). Our overarching hypothesis is that understanding the B cell response in individuals who naturally control infections, or who have been vaccinated, can help us to understand the basic biology behind successful immune responses, and lead to design of more effective vaccines.

Publications and Interests: https://jhu.pure.elsevier.com/en/persons/justin-bailey