Research:

Key words: immunoassay development, human immunology, precision immunopathology

The Larman laboratory develops and deploys new technologies to study the human immune system. Much of our work leverages advances in high throughput DNA synthesis and sequencing to enable novel, highly multiplexed molecular assays. Examples include:

– phage display of synthetic peptidome libraries for comprehensive profiling of antibodies;

– ribosome display of ORFeome libraries for antigen discovery, protein-protein interaction studies, and drug target identification;

– ultrasensitive, multiplexed RNA quantification techniques to monitor gene expression and detect microbes;

– efficient T cell receptor repertoire analysis;

– pooled genetic screening to elucidate immune cell function and identify new therapeutic targets.

The laboratory uses these and other unbiased approaches to identify new opportunities for monitoring and manipulating immune responses.

Publications and Interests: https://jhu.pure.elsevier.com/en/persons/harry-larman